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H2020 ROBOX

Good review of this essentiial feature of Cytochrome P450s for application 

http://www.sciencedirect.com/science/article/pii/S1570963917301802?via%3Dihub

Highlights

Thermostability is a desirable feature for using P450s in industrial processes

The structures of four P450s from thermophiles have been characterized to date.

P450s from thermophiles tend to be shorter overall than those from mesophiles.

Extended salt-bridged and aromatic networks may stabilize the P450 fold.

Directed evolution has been used to increase the thermostability of mesophilic P450s.