Good review of this essentiial feature of Cytochrome P450s for application
Thermostability is a desirable feature for using P450s in industrial processes
The structures of four P450s from thermophiles have been characterized to date.
- P450s from thermophiles tend to be shorter overall than those from mesophiles.
Extended salt-bridged and aromatic networks may stabilize the P450 fold.
Directed evolution has been used to increase the thermostability of mesophilic P450s.